Eight contacts refused treatment. Funding Statement The authors received no specific funding for this work. Subjects were recruited to this study consecutively. The result of the test was considered undetermined if an antigen-stimulated sample was negative and the value of the positive control was less than 0. J Glob Infect Dis.
The results of this observational study support our hypothesis that the use of QFT-GIT for targeting BCG-vaccinated TB contacts for preventive therapy is as effective as a TST-based strategy for preventing subsequent development of TB, while allowing a substantial reduction of treatment prescriptions.
QuantiFERON-TB Gold In-Tube test in active tuberculosis patients and healthy adults
Up to approximately ten years ago, the diagnosis of TB infection relied exclusively on the tuberculin skin test TST. Received Mar 19; Accepted Aug 1. A undetermined or uninterpretable result was found among the group of active PTB patients in two cases due to the low immune response to mitogen antigen in a positive control tube. At least, 5, bacilli per mL of sputum are required for a smear-positive result. As regards treatment, courses of preventive treatment were prescribed. This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Therefore, high rates of BCG vaccination should not be a concern of use in this setting and elsewhere.